The lower two shelves of my Amerique are always hotter than the top two so I rotate.
Over Thanksgiving I smoked a 14.5 lb boneless Ribeye with one chunck of Hickory at 250 for 2.5 hours, then 140 for another 2.5 hours until it hit 121 degrees, then I let it rest covered for more than an hour before slicing.
It was terrific with just a "Kiss" of smoke flavor which my guests really enjoyed. Ribeye and NY Strip Roasts seem to pick up a lot of smoke quickly so I went easy on the wood.
I plan on repeating my experiment next week for Christmas and will probably keep it at 250 for a little longer before taking it down to 140.
Have fun!