Sure they work, but as it's your first post, I have to ask why? In my 12 years of the forum, it's usally a question asked because you haven't been successful cooking brisket. Is that the case?
Me? I like the flavor of brisket to be brisket. Not pot roast or something else (at home, it never touches foil), to me it's all about the meat.
Are you wanting different flavors, we can help with some techniques