I think if there is alot of bark on the wood and you are doing a short cook and do not let it burn off first and the bark smolders away and all the wood does not, some bark might be bitter and adversely flavor the meat.
In my experience, bark does make a difference in some circumstances, but overall it does not. The exceptions are:
1. Never use the bark of Alder. It should be removed when it is being cut. 2. Bark that is loaded with mold. 3. Wood cuts made up of more than 30% bark.
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