Something to ponder upon.
The plateau that we deal with on tough cuts of meat,has to deal with the break down of collagen and the rendering of fat.
The 150�-160� that may take three hours plus,at low temps, accounts for the tenderness,lack of fat,and retained moisture.
Water boils off at 212�,depending on altitude.
A nine lb butt may take 18 hrs at 225�-235� to render lean,moist and pullable at 195� internal.
A 16 lb packer may take twenty hrs.
It has taken a long time for that to break down.
you can take a quarter inch slice ,with the grain,on a packer -or butt-,cook it to 195� in a 325� skillet in two minutes and you can't reduce it with a sausage grinder,much less chew it.
What I'm posing is that each cell needs the slow and low,over time to tender.
What I'm offering is that ,if you have a nine lb butt,or a sixteen lb packer brisket,the weight X hrs X temp ,may sorta work.
Just my $0.02 worth.